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Ephedrine promotes modest short-term weight loss, specifically fat loss, but its long-term effects are unknown. In mice, ephedrine is known to stimulate thermogenesis in the brown adipose tissue, but because adult humans have only small amounts of brown fat, thermogenesis is assumed to take place mostly in the skeletal muscle.

Ephedrine also decreases gastric emptying. Methylxanthines such as caffeine and theophylline have a synergistic effect with ephedrine with respect to weight loss. This led to creation and marketing of compound products.

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Fentanyl, also spelled fentanil, is a powerful opioid used as a pain medication and together with other medications for anesthesia. It is also used as a recreational drug, sometimes mixed with heroin, methamphetamine, or cocaine. It has a rapid onset and its effects generally last under two hours. Medically, it is used by injection, nasal spray, skin patch, or absorbed through the cheek as a lozenge or tablet

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